张杰

职称：讲师

邮箱：zhuji29@163.com

个人主页链接（如果在其他地方有信息较全的个人主页，如ResearchGate，学校的机构知识库等）

个人简介

张杰，男，博士。本科和硕士毕业于东北农业大学， 2011年于山东农业大学获得博士学位，同年进入山东农业大学畜牧学博士后流动站。2014年7月入职山东农业大学动物科技学院，主讲《动物组织胚胎学》、《动物生物技术》等课程。主要从事哺乳动物生殖细胞和胚胎发育的研究。近年来在《Biology of Reproduction》、《Aging (Albany NY)》等国际期刊发表SCI论文24篇，其中第一作者4篇。

教育经历

2011 - 2014 , 博士后 , 畜牧学 , 山东农业大学

2008 - 2011 , 农学博士 , 基础兽医学, 山东农业大学

2005 - 2008 , 农学硕士 , 基础兽医学, 东北农业大学

2000 - 2004 , 农学学士 , 动物科学, 东北农业大学

工作经历

2014 - 至今 , 讲师 , 山东农业大学动物科技学院

执教课程

动物组织胚胎学（本科生）

动物生物技术（本科生）

研究领域

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本实验室主要研究领域

1. 哺乳动物卵母细胞发育与成熟机理

2. 应激对雄性生殖细胞发育的影响

3. 哺乳动物早期胚胎发育

卵母细胞生发泡染色质构型；生发泡物质在卵母细胞成熟中的作用；心理应激对精子发育的影响机制；DNA拓扑异构酶与纺锤体组装检验点在卵母细胞第一次减数分裂中的作用机制以及卵母细胞排卵后老化miRNAs的变化。

发表文章、专利

1.Zhang J, Cui W, Li Q, Wang T-Y, Sui H-S, Wang J-Z, Luo M-J and Tan J-H. (2013). Mechanisms by which a Lack of Germinal Vesicle (GV) Material Causes Oocyte Meiotic Defects: A Study Using Oocytes Manipulated to Replace GV with Primary Spermatocyte Nuclei. Biology of Reproduction. 89, 83.

2.Wang T-Y, Zhang J, Zhu J, Lian H-Y, Yuan H-J, Gao M, Luo M-J and Tan J-H. (2017). Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes. Aging. 9, 1186-1201.

3.Zhang J, Kong D-L, Xiao B, Yuan H-J, Kong Q-Q, Han X, Luo M-J and Tan J-H. (2020). Restraint stress of male mice triggers apoptosis in spermatozoa and spermatogenic cells via activating the TNF-α system. Zygote. 28, 160-169.

4.Zhang J, Yuan H-J, Zhu J, Gong S, Luo M-J and Tan J-H. (2022). Topoisomerase II dysfunction causes metaphase I arrest by activating Aurora B, SAC and MPF and prevents PB1 abscission in mouse oocytes. Biology of Reproduction. 106, 900-909.

5. Cui W, Zhang J, Lian H-Y, Wang H-L, Miao D-Q, Zhang C-X, Luo M-J and Tan J-H. (2012). Roles of MAPK and Spindle Assembly Checkpoint in Spontaneous Activation and MIII Arrest of Rat Oocytes. PLoS ONE. 7, e32044.

6.Pan L-Z, Cheng H, Zhang J, Gong S, Tian X-D, Pan C-J, Luo M-J and Tan J-H. (2021). Invivo zearalenone exposure dose-dependently compromises mouse oocyte competence by impairing chromatin configuration and gene transcription. Reproduction, Fertility and Development. 33, 229-238.

7.Tan X-W, Ji C-L, Zheng L-L, Zhang J, Yuan H-J, Gong S, Zhu J and Tan J-H. (2017). Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study. Human Reproduction. 32, 1583-1597.

8.Wen J, Wang G-L, Yuan H-J, Zhang J, Xie H-L, Gong S, Han X and Tan J-H. (2020). Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes. Scientific Reports. 10, 2782.

9. Liu X-Y, Miao Y-L, Zhang J, Qiu J-H, Cui X-Z, Gao W-Q, Luo M-J and Tan J-H. (2012). Effects of Activation on Functional Aster Formation, Microtubule Assembly, and Blastocyst Development of Goat Oocytes Injected with Round Spermatids. Cellular Reprogramming. 14, 436-447.

10.Xie H-L, Zhu S, Zhang J, Wen J, Yuan H-J, Pan L-Z, Luo M-J and Tan J-H. (2018). Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference. Journal of Cellular Physiology. 233, 6952-6964.

11.Yang R, Sun H-H, Ji C-L, Zhang J, Yuan H-J, Luo M-J, Liu X-Y and Tan J-H. (2017). Role of calcium-sensing receptor in regulating spontaneous activation of postovulatory aging rat oocytes. Biology of Reproduction. 98, 218-226.