浏览次数：2861
职称：副教授
邮箱：zhaoxn@sdau.edu.cn
办公室电话：0538-8242593-8201
教育经历
2016 - 2021 , 博士后 , 兽医学, 山东农业大学
2006 -2011 , 农学博士, 临床兽医学, 南京农业大学
2000 - 2005 , 农学学士 , 动物医学, 河南科技学院
工作经历
2016 - 至今 , 副教授 , 山东农业大学
2011 - 2015 , 副教授 , 山东农业大学
执教课程
中兽医学基础、中兽医临床应用（本科生）
药理学与中兽医学、兽药创制与应用（研究生）
研究领域
本实验室主要研究领域
1. 中兽药药效及作用机制
2. 中兽药研发
开展以白术多糖、桔梗多糖、玉屏风多糖等为核心的中药多糖研制，研制优质高效的中药多糖免疫增效剂，充分运用分子病毒学、免疫学、生物学、宏基因组学、代谢组学等技术和试验方法，研究中药多糖抗病毒及调节免疫、抗炎、抗凋亡、抗氧化等协同抗病毒机制，提高抗病毒中药多糖的药理研究水平。
承担的科研项目
PGPSt靶向SPHK1调控FB1诱导猪肺泡巨噬细胞死亡的作用机制，ZR2021MC088，山东省自然科学基金面上项目，2022.1- 2024.12，主持
天然防御因子兽药创制关键技术与产业化，山东省重大科技创新工程项目子课题，2019.11-2021.12，主持
基于细胞自噬和凋亡研究桔梗多糖的增强免疫作用和机理，ZR2017MC026，山东省自然科学基金面上项目，2017.8- 2020.6，主持
白术多糖调控巨噬细胞自噬和凋亡的作用和机理研究，中国博士后科学基金特别资助，2017T100505，2017.6-2020.6，主持
桔梗多糖调控鸡腹腔巨噬细胞功能及TLR4信号通路研究，中国博士后科学基金面上项目，2016M592232，2016.3-2019.3，主持
白术多糖和桔梗多糖对免疫抑制鸡Th17/Treg失衡的调节及其机制，山东省博士后创新专项基金，201603051，2016.12-2019.12，主持
玉屏风活性多糖对雏鸡的免疫增强作用及机理研究，山东省自然科学基金青年基金项目，2012.7-2015.7，主持
发表文章、专利
1.赵晓娜，牛家强，胡元亮，黄小燕，王君敏，朱广双. 12种藏药对鸡法氏囊病毒感染鸡胚成纤维细胞能力的影响. 江苏农业学报，2009, 25 (1) : 219-221.
2.赵晓娜，牛家强，胡元亮，王君敏，黄小燕，卢 宇，张 帆，郑铁锁.12 种藏药对鸡胚成纤维细胞的安全浓度和生长的影响. 中国兽医学报，2009 , 29 (4) :511-513, 518.
3.赵晓娜，刘建柱，程国栋，邓干臻，李克鑫，李克钦，刘国涛，李雯. 桔梗多糖通过自噬在拮抗伏马毒素B1诱导的细胞凋亡中的用途. ZL 2020 1 0189615.9. 国家发明专利. 国家知识产权局，2021.12.2
4.赵晓娜 刘建柱 王成 程国栋. 桔梗总多糖在制备治疗由CCCP诱导的细胞凋亡的药物中的应用. ZL 201910510952.0，国家发明专利. 国家知识产权局，2022.5.26
5. 赵晓娜，孙文静，刘建柱，马藤菲，郝盼，王胜华. 一种新城疫疫苗玉屏风多糖免疫增强剂 ZL 201510385579.2. 国家发明专利. 国家知识产权局，2018.6.5
6.Guodong Cheng#, Shijie Zhang#, Meiyun Lv, Changxi Qi, Rupeng Fan, Xiaocheng Guo, Jianzhu Liu*, Xiaona Zhao*. The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy. Phytomedicine 103 (2022) 154212.
7.Cheng Wang#, Changxi Qi#, Mingchao Liu, Lumei Wang, Guodong Cheng, Liping Li, Yuxiao Xing, Xiaona Zhao*, Jianzhu Liu*. Protective effects of agrimonolide on hypoxia‐induced H9c2 cell injury by maintaining mitochondrial homeostasis. Journal of cellular biochemistry. 2022, 123(2):306-321.
8.Changxi Qi#, Liping Li#, Guodong Cheng, Bin Xiao, Yuxiao Xing, Xiaona Zhao*, Jianzhu Liu*. Platycodon grandiforus Polysaccharide with Anti Apoptosis, Anti Oxidant and Anti Infammatory Activity Against LPS/D GalN Induced Acute Liver Injury in Mice. Journal of Polymers and the Environment. 2021, 29:4088–4097.
9.Shuo Zhang#, Xiaona Zhao#, Jiajia Hao, Yiran Zhu, Yue Wang, Lumei Wang, Shuhua Guo, Hui Yi, Yongxia Liu, Jianzhu Liu*. The role of ATF6 in Cr(VI)-induced apoptosis in DF-1 cells. Journal of Hazardous Materials. 2021, 410:124607.
10. Jiajia Hao#, Yafen Song, Bin Tian, Changxi Qi, Liping Li, Lumei Wang, Yuxiao Xing,Xiaona Zhao*, Jianzhu Liu*. Platycodon grandifloras polysaccharides inhibit mitophagy injury induced by Cr (VI) in DF-1 cells. Ecotoxicology and Environmental Safety. 2020, 202:110901.
11. Cheng Wang#, Guodong Cheng, Shujuan Yang, Liping Li, Youpeng Zhang, Xiaona Zhao*, Jianzhu Liu*. Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells. International Journal of Biological Macromolecules. 2019, 141:1220-1227.
12. Pimiao Zheng#, Wentao Fan, Shenghua Wang, Pan Hao, Yang Wang, Huiyu Wan, Zhihui Hao, Jianzhu Liu*, Xiaona Zhao*. Characterization of polysaccharides extracted from Platycodon grandifloras (Jacq.) A.DC. affecting activation of chicken peritoneal macrophages, International Journal of Biological Macromolecules. 2017, 96:775-785.
13. Xiaona Zhao#, Yuge Wang#, Peng Yan, Guodong Cheng, Cheng Wang, Na Geng, Xuepeng Wang, Jianzhu Liu*. Effects of Polysaccharides from Platycodon grandiflorum on Immunity-Enhancing Activity In Vitro. Molecules. 2017, 22(11): E1918.
14. Wentao Fan#, Pimiao Zheng, Yang Wang, Pan Hao, Jianzhu Liu*, Xiaona Zhao*. Analysis of Immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo, Biomedicine & Pharmacotherapy. 2017, 93:146-155.
15. Wentao Fan#, Shijie Zhang#, Pan Hao, Pimiao Zheng, Jianzhu Liu*, Xiaona Zhao*. Structure characterization of three polysaccharides and a comparative study of their immunomodulatory activities on chicken macrophage. Carbohydrate polymers. 2016, 153: 631-640.
16. Xiaona Zhao#, Wenjing Sun#, Shijie Zhang, Guangju Meng, Chunhua Qi, Wentao Fan, Yuge Wang, Jianzhu Liu*. The immune adjuvant response of polysaccharides from Atractylodis macrocephalae Koidz in chickens vaccinated against Newcastle disease (ND)，Carbohydrate polymers. 2016, 141:190-196.
17. Yanhan Liu#, Xiaona Zhao#, Xiao Zhang, Xuejun Zhao, Yongxia Liu, Jianzhu Liu*. Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken. BIOLOGICAL TRACE ELEMENT RESEARCH, (2016) 171:459–467.
18. Wenjing Sun#, Kai Meng#, Chunhua Qi, Xianyong Yang, Yuge Wang, Wentao Fan, Zhengui Yan, Xiaona Zhao*, Jianzhu Liu*. Immune-enhancing activity of polysaccharides isolated from Atractylodis macrocephalae Koidz. Carbohydrate polymers. 2015, 126:91-96.
19. WenTao Fan#, XiaoNa Zhao#, Jia Cheng, YanHan Liu, JianZhu Liu*. Oxidative Stress and Hepatocellular Injury Induced by Oral Administration of Cr3+ in Chicken. Journal of BIOCHEM and MOLECULAR TOXICOLOGY. 2015, 29(6):280-287.
20. Xiaona Zhao#, Jianzhu Liu*. Scutellaria polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. Journal of the Science of Food and Agriculture. 2014, 94(4):779-784.
21. Y Bai#, X Zhao#, C Qi, L Wang, Z Cheng, M Liu, J Liu*, D Yang, S Wang, T Chai. Effects of chromium picolinate on the viability of chick embryo fibroblast. Human and Experimental Toxicology. 2014, 33(4) 403–413.
22. Xiaona Zhao#, Yuanliang Hu*, Deyun Wang, Jianzhu Liu, Liwei Guo. The comparison of immune-enhancing activity of sulfated polysaccharidses from Tremella and Condonpsis pilosula. Carbohydrate polymers. 2013, 98: 438-443.
23. Xiaona Zhao#, Yuanliang Hu*, Deyun Wang, Liwei Guo, Shujuan Yang, Yunpeng Fan, Bingkai Zhao, Yuanlei Wang, Saifuding Abula. Optimization of sulfated modification conditions of tremella polysaccharide and effects of modifiers on cellular infectivity of NDV. International Journal of Biological Macromolecules. 2011, 49:44–49.
24. Xiaona Zhao#, Yanfei Bai#, Jianzhu Liu*, Shujing Wang, Tongjie Chai. Essenceof Traditional Chinese Medicine Syndromes Based on the Metabolomic Approach in China. International Journal of Biotechnology and Allied Fields (IJBAF) 2013, 1(2): 85-97.