姓名：刘永夏

职称：副教授

邮箱：liuyongxia@sdau.edu.cn

办公室电话：0538-8242478

个人简介

刘永夏（1987-），男，山东农业大学动物科技学院临床兽医学系副教授，硕士生导师。

教育经历

2012 – 2015, 农学博士 , 临床兽医学系 , 中国农业大学

2009 - 2012 , 农学硕士 , 临床兽医学系 , 山东农业大学

2005 - 2009 , 农学学士 , 动物医学专业 , 山东农业大学

工作经历

2020 - 至今 , 副教授 , 山东农业大学动物科技学院

2015 - 2020 , 讲师 , 山东农业大学动物科技学院

荣誉奖励

2020年山东农业大学一流课程《兽医临床诊断学》第二位

2020年山东农业大学教学成果二等奖第三位

2021年山东农业大学教学成果二等奖第二位

执教课程

兽医临床诊断学（本科生）

特种经济动物疾病学（本科生）

宠物观赏与管理（本科生）

研究领域

 本实验室主要研究领域：

 1. 细菌胞内存活的机制研究

 2. 畜禽的重金属毒理学机制研究

 3. 畜禽普通病发病机理及综合防控技术研究

 承担的科研项目：

 1.国家自然科学基金青年项目，TFEB与p38α MAPK Crosstalk调控金黄色葡萄球菌抑制牛乳腺上皮细胞自噬降解的机制（31802259），2019.1-2021.12，经费25.0万元。

 2.中国博士后科学基金特别资助，ULK1调控金葡菌抑制牛乳腺细胞自噬-溶酶体融合的机制（2019T120601），2019.7-2021.12，经费18.0万元。

 3.山东省重点研发计划科技攻关项目，犊牛摩氏摩根菌病综合防控技术研究（2019GNC106141），2019.1-2021.12，经费15.0万元。

发表文章、专利

1.Wang X, Liu M, Geng N, Du Y, Li Z, Gao X, Han B, Liu J, Liu Y. Staphylococcus aureus mediates pyroptosis in bovine mammary epithelial cell via activation of NLRP3 inflammasome. Veterinary Research. 2022, 53(1): 10. doi: 10.1186/s13567-022-01027-y. (Corresponding Author)

2.Geng N, Gao X, Wang X, Cui S, Wang J, Liu Y, Chen W, Liu J. Hydrogen helps to ameliorate Staphylococcus aureus-induced mastitis in mice. International Immunopharmacol. 2022, 109: 108940. doi: 10.1016/j.intimp.2022.108940. (Corresponding Author)

3.Qi M, Geng H, Geng N, Cui Y, Qi C, Cheng G, Song K, Hu L, Liu Y, Liu J, Han B. Streptococcus agalactiae-induced autophagy of bovine mammary epithelial cell viaPI3K/AKT/mTOR pathway. Journal of Dairy Research. 2022, 7: 1-7. doi: 10.1017/S0022029922000243. (Corresponding Author)

4.Wang R, Zhang W, Wang L, Geng N, Wang X, Zhang M, Liu J, Liu Y, Han B. Intracellular Staphylococcus aureus inhibits autophagy of bovine mammary epithelial cells through activating p38α. Journal of Dairy Research. 2021, 88(3): 293-301. doi: 10.1017/S0022029921000649. (Corresponding Author)

5.Zhang S, Zhao X, Hao J, Zhu Y, Wang Y, Wang L, Guo S, Yi H, Liu Y, Liu J. The role of ATF6 in Cr(VI)-induced apoptosis in DF-1 cells. Journal of Hazardous Materials. 2020, 19: 124607. doi: 10.1016/j.jhazmat.2020.124607. (Corresponding Author)

6.Geng N, Wang X, Yu X, Wang R, Zhu Y, Zhang M, Liu J, Liu Y. Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function [J]. Frontiers in Immunology, 2020: 11(746). doi:10.3389/fimmu.2020.00746. (Corresponding Author)

7.Wang X, Su F, Yu X, Geng N, Li L, Wang R, Zhang M, Liu J, Liu Y, Han B. RNA-Seq Whole Transcriptome Analysis of Bovine Mammary Epithelial Cells in Response to Intracellular Staphylococcus aureus. Frontiers in Veterinary Science. 2020, 7: 642. doi: 10.3389/fvets.2020.00642. (Corresponding Author)

8.Geng N, Liu K, Lu J, Xu Y, Wang X, Wang R, Liu J, Liu Y, Han B. Autophagy of bovine mammary epithelial cell induced by intracellular Staphylococcus aureus[J]. Journal of Microbiology, 2020: 1-10. doi: 10.1007/s12275-020-9182-8. (Corresponding Author)

9.Liu K, Cui Y, Li H, Qi C, Cheng G, Gao X, Zhang Z, Liu Y, Liu J. Hydrogen-Rich Medium Regulates Cr(VI)-Induced ER Stress and Autophagy Signaling in DF-1 Cells. Biological Trace Element Research. 2022, 200(5): 2329-2337. doi: 10.1007/s12011-021-02850-8. (Corresponding Author)

10.Xing Y, Wang L, Xu G, Guo S, Zhang M, Cheng G, Liu Y, Liu J. Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy. Research in Veterinary Science. 2021, 140:18-25. doi: 10.1016/j.rvsc.2021.08.004. (Corresponding Author)

11.Zhu Y, Wang L, Yu X, Jiang S, Wang X, Xing Y, Guo S, Liu Y, Liu J. Cr(VI) promotes tight joint and oxidative damage by activating the Nrf2/ROS/Notch1 axis. Environmental Toxicology Pharmacology. 2021, 85: 103640. doi: 10.1016/j.etap.2021.103640. (Corresponding Author)

12.Wang Y, Wang X, Wang L, Cheng G, Zhang M, Xing Y, Zhao X, Liu Y, Liu J. Mitophagy Induced by Mitochondrial Function Damage in Chicken Kidney Exposed to Cr(VI). Biological Trace Element Research. 2021, 199(2): 703-711. doi: 10.1007/s12011-020-02176-x. (Corresponding Author)

13.Xu Y, Wang X, Geng N, Zhu Y, Zhang S, Liu Y, Liu J. Mitophagy is involved in chromium (VI)-induced mitochondria damage in DF-1 cells. Ecotoxicology and Environmental Safety, 2020, 194: 110414. doi: 10.1016/j.ecoenv.2020.110414. (Corresponding Author)

14.Wang S, Geng N, Zhou D, Qu Y, Shi M, Xu Y, Liu K, Liu Y, Liu J. Oral Immunization of Chickens with Recombinant Lactobacillus plantarum Vaccine Against Early ALV-J Infection. Frontiers in Immunology, 2019, 10: 2299. doi: 10.3389/fimmu.2019.02299. (Corresponding Author)

15.Liu K, Chen P, Lu J, Zhu Y, Xu Y, Liu Y, Liu J. Protective Effect of Purple Tomato Anthocyanidin on Chromium (VI)-Induced Autophagy in LMH Cells by Inhibiting Endoplasmic Reticulum Stress. Biological Trace Element Research, 2019. https://doi.org/10.1007/s12011-019-01795-3. (Corresponding Author)

16.Cheng J, Xu Y, Zhou D, Liu K, Geng N, Lu J, Liu Y, Liu J. Novel carbon quantum dots can serve as an excellent adjuvant for the gp85 protein vaccine against avian leukosis virus subgroup J in chickens. Poultry Science, 2019, 98(11): 5315-5320. (Corresponding Author)

17.Zhu Y, Xu G, Chen P, Liu K, Xu Y, Liu Y, Liu J. Effects of Cr (VI)-induced calcium-sensing receptor activation on DF-1 cell pyroptosis. Ecotoxicology and Environmental Safety, 2019, 179: 257-264. (Corresponding Author)

18.Chen P, Geng N, Zhou D, Zhu Y, Xu Y, Liu K, Liu Y, Liu J. The regulatory role of COX-2 in the interaction between Cr (VI)-induced endoplasmic reticulum stress and autophagy in DF-1 cells. Ecotoxicology and Environmental Safety, 2019, 170: 112-119. (Corresponding Author)

1.刘永夏, 刘建柱, 张美华, 邓干臻, 李克鑫, 韩博, 才冬杰, 张立梅, 胡莉萍.一种检测摩氏摩根菌抗体的间接ELISA检测试剂盒及应用，2022-4-29，中国，CN113063942 B.（专利）

2.刘建柱, 张美华, 刘永夏, 韩博, 才冬杰, 左之才, 邓干臻, 李克鑫. 菌液直接PCR检测摩根氏菌的方法, 2020-2-25, 中国, CN202010114819.6. （专利）

3.刘建柱, 刘永夏, 耿娜, 李克鑫, 李克钦, 邓干臻, 王晓舟, 刘康平, 王润. 自噬调节剂在消除牛乳腺上皮细胞内金黄色葡萄球菌中的应用, 2018-12-10, 中国, CN201811504688.1（专利）