张桂国，山东农业大学动物科技学院，副院长，教授、博士生导师，学科主任。
联系方式：山东省泰安市泮河大街7号山东农业大学动物科技学院，271000
电话：0538-8241544
个人简介
张桂国，教授，博士生导师，动物科技学院副院长，学科主任。营养与代谢方向学科带头人，山东省牧草产业体系副首席岗位科学家，国家十四五重点研发项目首席专家，山东省功能性多糖国际联合实验室主任，农业农村部非粮饲料高效利用重点实验室常务副主任，山东省青年骨干教师，农村农业部饲料安全评审委员会专家，山东畜牧兽医学会副秘书长，反刍动物科技专业委员会主任委员，草业科技专业委员会秘书长。先后在美国加州大学戴维斯分校、新西兰皇家农业科学院、新西兰林肯大学、北京大学生命科学院做访问学者。担任Nutrition Research and Practice杂志编委；近五年，以第一或通讯作者发表SCI论文50余篇。获山东省科技进步二等奖2项、神农中华农业科技奖2项，发明专利8项，主持制定山东省地方标准10项。当前主持国家重点研发计划、山东省重点研发计划，山东省牧草产业体系，山东省良种工程，农业农村部行业专项等重大科研项目10余项。
执教课程
分子营养（博士）
饲料科学、新型饲料添加剂（硕士）
Animal nutrition（英文）（本科生 中美合作培养）
饲料分析 （本科生）
研究领域
本实验室主要研究领域
1.利用组学技术研究食品膳食纤维（功能型多糖）/功能性养分调控肠道微生物组、代谢组、转录组的途径来影响宿主生理、生长发育、食品品质的内在机制；
2.营养与代谢：饲料养分、食品/饲料功能性成分代谢规律及对畜产品品质调控的组学机制；
3.牧草产业：青贮玉米及优质牧草品种选育、高效生产技术；草畜一体化建设关键技术的研究、集成与示范。
承担的科研项目
1.主持 国家农业重大科技项目 “优质牧草抗寒性评价指标体系在不同生态区的优化与应用（NK20221403）2022.11-2026.12；500万。
2.主持 山东省重点研发项目“绿色高效智能畜禽工厂化关键技术创新与应用示范
2022TZXD0018”2022-2026.426万。
3.山东省功能型多糖国际联合实验室及人才工程项目，2024-2029，500万。
4.主持 国家重点研发项目“陆生/海洋植物中功能性多糖构效关系与生物学活性分子机制研究（2019YFE0107700）2020.7-2024.6；143万。
5.山东省牧草产业体系岗位科学家 饲草营养岗位（SDAIT-23-05）2021-2025年；125万。
6.农业部“粮改饲”重大专项 青贮玉米在肉羊健康养殖中的应用 2020-2025年；80万。
7.山东省良种工程项目“黄河三角洲肉用绵羊青粗饲料供应综合配套技术研究”（2021-2026，周期滚动项目）。
8.山东省农业良种工程“南种北繁”项目 LZ201712080160 2018-2024。
发表文章 (第一或通讯作者文章)
1. Anxin Liu1, Eunyoung Kim2, Jiamei Cui2, Jing Li1, Yunkyoung Lee 2,3, †, Guiguo Zhang1, †
Laminaria japonica polysaccharide improved the productivities and systemic health of ducks by mediating the gut microbiota and metabolome. Journal of Agricultural and Food Chemistry 2023, 5. Q1, 1 Top, IF= 5.895.
2. Chongyu Zhang, Eunyoung Kim, Jiamei Cui, Yunpeng Wang, Yunkyoung Lee*, Guiguo Zhang*. Influence of the ecological environment on the structural characteristics and bioactivities of polysaccharides from alfalfa (Medicago sativa L.). Food and Function. 2022, 4. Q1, 2 Top, IF= 6.317.
3. Guiguo Zhang*, Yunkyoung Lee*, Zeng-Yu Wang and Yuxi Wang. Editorial: Synthesis and Bioactivities of Plant-Derived Biomolecules Frontiers in plant science. 2022, 7. Q1, Top, IF= 6.627.
4. Guiguo Zhang*, Yunkyoung Lee *, Yang Liu, and Yanlin Hao. Editorial: The Mechanism of Plant-derived Polysaccharides Regulating the Obesity and Metabolic Diseases in Humans. Frontiers in nutrition. 2022, 8. Q1, Top, IF= 6.59.
5. Jiamei Cui, Yunpeng Wang, Eunyoung Kim, Chongyu Zhang, Guiguo Zhang*, Yunkyoung Lee* Structural characteristics and immunomodulatory effects of a long-chain polysaccharide from Laminaria Japonica. Frontiers in nutrition. 2022, 3. Q1, 1 Top, IF= 6.59.
6. Siqi Li, Meiyu Du, Chongyu Zhang, Yun Wang, Yunkyoung Lee*, Guiguo Zhang* Diet type impacts production performance of fattening lambs by manipulating the ruminal microbiota and metabolome. Frontiers in microbiology. 2022, 4. Q1, 2 Top, IF= 6.064.
7. Eunyoung Kim, Jiamei Cui, Guiguo Zhang*, Yunkyoung Lee* Physiological Effects of Green‐Colored Food‐Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases Applied Science. 2022,12,1879. 3, IF=2.679.
8. Chongyu Zhang, Chen Zhang, Yunpeng Wang, Meiyu Du, Guiguo Zhang*, Yunkyoung Lee* Dietary Energy Level Impacts the Performance of Donkeys by Manipulating the Gut Microbiome and Metabolome Frontiers in veterinary science. 2021, 8, 694,357. Q1, 2, IF= 3.471.
9. Zemin Li, Chen Zhang, Shimin Zhang, Bo Li, Chong-Yu Zhang, Fawaz G Haj, Guiguo Zhang*, Yunkyoung Lee* The Intestinal Microbiota Characteristics of Salmonella-challenged Broilers and the Modulatory Effects of Alfalfa Polysaccharide on Intestinal Health. Scientific Reports. 2021,11:10910. 3, IF= 4.379.
10. Chen Zhang, Chongyu Zhang, Meiyu Du, Yunpeng Wang, Guiguo Zhang*, Yunkyoung Lee* Effects of dietary supplementation with different fermented feeds on performance, nutrient digestibility, and serum biochemical indexes of fattening lambs. Animal Bioscience. 2021.34.4:633-641. Q1, IF=2.509.
11. Eunyoung Kim, Jiamei Cui, Inhae Kang, Guiguo Zhang*, Yunkyoung Lee* Potential Antidiabetic Effects of Seaweed Extracts by Upregulating Glucose Utilization and Alleviating Inflammation in C2C12 Myotubes. 2021 International Journal of Environmental Research and Public Health. Q1, 3 Top, IF= 3.390.
12. A-Reum Han, Jae-Hoon Kim, Eunyoung Kim, Jiamei Cui, In-suk Chai, Guiguo Zhang,* Yunkyoung Lee* Hypotriglyceridemic effects of brown seaweed consumption via regulation of bile acid excretion and hepatic lipogenesis in high fat diet-induced obese mice. Nutrition Research and Practice. 2020, 14, 6, 580-592. IF=1.792.
13. Chen Zhang, Zemin Li, Chong-Yu Zhang, Mengmeng Li, Yunkyoung Lee, Guiguo Zhang* Extract Methods, Molecular Characteristics, and Bioactivities of Polysaccharide from Alfalfa (Medicago sativa L.) Nutrients. 2019,11 (5)1181-1196. 2 Top, IF= 4.171.
14. Hyo-Seon Yang, Fawaz G Haj, Myoungsook Lee, Inhae Kang, Guiguo Zhang, Yunkyoung Lee*. Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells Nutrients. 2019,11,1001 2 Top, IF= 4.171.
15. Zhang, C Y, Gan, L P, Du M Y, Shang, Q H, Xie, Y H, Zhang, G G* Effects of dietary supplementation of alfalfa polysaccharides on growth performance, small intestinal enzyme activities, morphology, and large intestinal selected microbiota of piglets. Livestock Science 2019. 223, 47-52.
16. Lixue Wang, Yuhuai Xie, WeirenYang, ZaibinYang, shuzhen Jiang, Chongyu Zhang & Guiguo Zhang*. Alfalfa polysaccharide prevents H2O2-induced oxidative damage in MEFs by activating MAPK/Nrf2 signaling pathways and suppressing NF-κB signaling pathways. Scientific Reports, 2019, 9:1782 （the corresponding author）（SCI, IF= 4.61）
17. Y.H. Xie, C.Y. Zhang, L.X. Wang, Q.H. Shang, G.G. Zhang*, W.R. Yang. Effects of dietary supplementation of Enterococcus faecium on growth performance, intestinal morphology, and selected microbial populations of piglets. Livestock science 2018,210, 111-117，（SCI, IF= 1.79）（the corresponding author）
18. J. Zhang, B.J.Yin, Y.H.Xie, J. LI, Z. B. Yang, and G. G. Zhang* Legume-cereal intercropping improves forage yield, quality and degradability Plos One 2015.12 DOI:10.1371/journal.pone.0144813 （SCI, IF= 3.36）
19. G. G. Zhang, Z. B. Yang, Y. Wang, W. R. Yang and H. J. Zhou. Effects of dietary supplementation of multi-enzyme on growth performance, nutrient digestibility, small intestinal digestive enzyme activities, and large intestinal selected microbiota in weanling pigs. J. Anim. Sci. 2014.92:2063–2069. （SCI, IF= 2.604）
20. Mengmeng Li, G. G. Zhang*, X.Z.Sun, S.O.Hoskin. New Zealand Studies on Methane Emissions from Pastoral Farming. Journal of Integrative Agriculture. 13(2): 365-377, 2014.（SCI, IF= 0.671）
21. Guiguo Zhang, Chongyu Zhang, Zaibin Yang，Shuting Dong. Root Distribution and N Acquisition in an Alfalfa and Corn Intercropping System. Journal of Agricultural Science. 5(9) 128-142, 2013. (SCI, IF=2.878）
22. G.G. Zhang, Z.B. Yang, Y. Wang, W.R. Yang. Effects of Astragalus Membranaceus Root Processed to Different Particle Sizes on Growth Performance, Antioxidant Status and Serum Metabolites of Broiler Chickens. Poultry Science. 92,178-183, 2013.（SCI, IF=1.516）
23. Guiguo Zhang, ZaibinYang，Qingqing Zhang. A multi-enzyme preparation enhances the utilization of nutrients and energy from pure corn and wheat diets in broilers. Applied Poultry Research, 1,67-78, 2012.（SCI, IF =0.846）
24. Guiguo Zhang, ZaibinYang, Shuting Dong. Interspecific competitiveness affects the total biomass yield in an alfalfa and corn intercropping system. Field Crops Research, 124,66-73, 2011.（SCI, IF=2.774）