赵孝民

浏览次数:5987




姓名: 赵孝民

职称:教授

邮箱:xmzhao66@sdau.edu.cn

办公室电话:824-9921

个人简介

赵孝民,山东农业大学教授,山东省政府参事。1982年一月毕业于山东农业大学, 兽医专业,学士学位。1984年十二月硕士研究生毕业于山东农业大学动物科技学院,获硕士学位。2001年一月博士研究生毕业于美国新墨西哥大学生物系,获博士学位(Ph.D with distinction)。 自1985年起,先后在山东农业大学动物科技学院,美国肯塔基大学兽医学院,美国新墨西哥大学生物系,美国依利诺大学香槟分校兽医学院,从事于主要从事动物寄生虫病病原的致病机理、免疫学、病原与宿主互作及寄生虫病的诊断与防治等方面的研究。2006年获美国依利诺大学5年科研工作成就奖。主持与参与美国NSFNIH国家重点研发计划课题、国家自然基金、省农业重大应用技术创新等科研课题十多项。现为美国寄生虫学家学会会员,中国畜牧兽医学会家畜寄生虫学分会常务理事,中国畜牧兽医学会动物福利与健康养殖分会常务理事。在国内外发表学术论文100多篇,主编及副主编专著3部。Journal of Immune Research杂志编委,Vaccine等十几种杂志审稿人

教育经

1996-07 2001-01, University of New Mexico, 生物系, 博士

1982-01 1984-12, 山东农业大学, 兽医专业, 硕士

1978-02 1982-01, 山东农学院, 畜牧兽医系兽医专业, 学士

博士后工作经历

2001-02 2002-08, University of Illinois

作经历

2011-03 至 今, 山东农业大学, 动物科技学院预防兽医系, 教授

2007-08 2011-02, 美国伊利诺依大学, 兽医学院病理生物学系, 研究型教授;山东农业大学兼职教授

2002-08 2007-07, 美国伊利诺依大学, 兽医学院病理生物学系, 研究型副教授

1994-11 1996-06,美国肯塔基大学,兽医学系,访问学者

1984-12 1994-10, 山东农业大学, 动物科技学院预防兽医系, 讲师

执教课程

兽医寄生虫病学(双语,本科生)

兽医学研究进展(研究生)

研究领域

实验室主要研究领域

1. 畜禽寄生原虫的致病机制

2. 畜禽寄生原虫病的综合防控

承担的科研项目

1. 国家基金委,国家自然基金面上项目,31172314, 应用基因随机致变提高鸡柔嫩艾美尔球虫EtMIC2 蛋白质保护性免疫原性的研究,2012-15, 64万元, 主持,

2. 山东省科技厅,省科技发展计划项目,2013GNC11017鸡球虫布拉氏酵母菌活载体疫苗的研究2013-201520万元,主持,

3. 山东省科技厅,省农业重大应用技术创新课题,中兽药高分子材料和制剂技术(泡腾技术)应用及生产关健技术研究,2013-201550万元主持,

4. 国家基金委,国家自然基金面上项目,31572514, 鸡柔嫩和巨型艾美尔球虫种特异性保护性抗原的筛选鉴定及其免疫特异性分子机制的研究,2016-2019,  80.4万元, 主持,

5. 中华人民共和国农业农村部, 国家重点研发计划, 2017YFD0500400, 畜禽重要胞内寄生虫的寄生虫免疫机制研究, 2017-09 2021-12, 358万元, 主持

国家发明专利

(1) 赵孝民; 陈正涛; 韩林臻; 李宏梅; 王方昆 ; 一种鸡柔嫩艾美尔球虫微线蛋#2突变体EtMIC2#1130, 2016-06-03, 中国, CN201610393266.6

(2) 赵孝民; 陈正涛; 韩林臻; 李宏梅; 王方昆 ; 一种鸡柔嫩艾美尔球虫微线蛋#2突变体EtMIC2#2119, 2016-06-03, 中国, CN201610390480.6.

发表文章、专利

5年代表性论著

1.Jing Qi1, Yang Gao1, Gui-sheng Wang, Lan-bo Li, Lu-lu Li, Xiao-min Zhao*, Yi-jun Du*, Yu-qing Liu*. Identification of Wohlfahrtiimonas chitiniclastica Isolated from an Infected Cow with Hoof Fetlow, China. Infection, Genetics and Evolution, 2016, Infection, Genetics and Evolution 41:174–176.

2.Cui Ning, Wang Xiuzhen, Wang Qi, Li Hongmei, Wang Fangkun, Zhao Xiaomin*. Effect of Dual Infection with Eimeria tenella and Subgroup J Avian Leukosis Virus on the Cecal Microbiome in Specific-Pathogen-Free Chicks, Front Vet Sci. 2017 Oct 25;4:177. doi: 10.3389/fvets.2017.00177.

3.Ma Xinjiang, Wang Qi, Li Hongmei, Xu ChuantianCui Ning, Zhao Xiaomin*. 16S rRNA genes Illumina sequencing revealed differential cecal microbiome in specific pathogen free chickens infected with different subgroup of avian leukosis viruses. Vet Microbiol. 2017 Aug;207:195-204. doi:10.1016/j.vetmic.2017.05.016.

4.Zhengtao Chen 1, Xiuzhen Wang 1, Ningning Zhao , Linzhen Han , Fangkun Wang, Hongmei Li ,Yanshun Cui *, Xiaomin Zhao*.Improving the immunogenicity and protective efficacy of the EtMIC2. Vaccine 36 (2018) 2435–2441. DOI:10.1016/j.vaccine.2018.03.046

5.Qian Du, Xingchen Wu, Tongtong Wang, Xuefeng Yang, Zhenyu Wang, Yingying Niu, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong and Yong Huang. Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings, J Immunol, 2018, 201 (2) 533-547; DOI: https://doi.org/10.4049/jimmunol.1800250

6.Xiangju Wu , Jing Qi, Xiaoyan Cong, Lei Chen, Yue Hu, Dongwan Yoo, Guisheng Wang, Fulin Tian, Feng Li, Wenbo Sun, Zhi Chen, Lihui Guo, iaqiang Wu, Jun Li, Jinbao Wang*, Xiaomin Zhao*, and Yijun Du*,Establishment and Characterization of a High and Stable Porcine CD163-Expressing MARC-145 Cell Line, BioMed Research International, 2018, Article ID 4315861, 9 pages, https://doi.org/10.1155/2018/4315861

7.Jiazhong Wang, Hongyan Zhang, HuijieDu, Fangkun Wang, Hongmei Li, Xiaomin Zhao *, Identification and characterization of Diutina rugosa SD-17 for potential use as a probiotic, LWT - Food Science and Technology 109 (2019) 283–288.

8.Jiazhong Wang, Bingxiang Wang,HuijieDu,Hongyan Zhang,Hongmei Li,Fangkun Wang,Xiaomin Zhao*, Effects of Diutina rugosa SD-17 on growth performance, intestine morphology, and immune status of chickens, Poultry Science,pez428, https://doi.org/10.3382/ps/pez428,Published: 27 July 2019

9.NingningZhao, Yue Jiang, ShuzhenMing, Sidang Liu, Xiaomin Zhao* and FangkunWang*,Monoclonal Antibody Preparation and Epitope Identification for Brucella melitensis Elongation Factor Tu. Front Microbiol. 2019, 10: 1878. Published online 2019 Aug 13. doi: 10.3389/fmicb.2019.01878

10.Ningning Zhao, Shuzhen Ming, Yaru Lu, Fangkun Wang, Hongmei Li, Xiao Zhang, Xiaomin Zhao*. Identification and application of epitopes in EtMIC1 of Eimeria tenella recognized by the mAb 1-A1 and 1-H2.Infection and Immunity, 2019.

11.Ningning Zhao, Junfeng Lv, J., Lu, Y., Jiang, Y., Li, H., Liu, Y., Zhang, X., Zhao, X., 2020. Prolonging and enhancing the protective efficacy of the EtMIC3-C-MAR against eimeria tenella through delivered by attenuated salmonella typhimurium. Vet Parasitol 279, 109061-109061.

12.Ruibiao Wang, Ningning Zhao, Hongyan Zhang, Fangkun Wang, Hongmei Li, Yumin Liu, Xiaomin Zhao,* and Xiao Zhang *, Prevalence of Toxoplasma gondii Infections in Chicken Hearts from Farmers’ Markets and Supermarkets in the Tai’an Region of China, Journal of Food Protection, Vol. 83, No. 2, 2020, Pages 338–341, https://doi.org/10.4315/0362-028X.JFP-19-374

13.Xiaonan Zhao†, Zijing Ju†, Guisheng Wang , Jie Yang , Fangkun Wang2, Hui Tang2, Xiaomin Zhao * and Shuhong Sun*, 2021. Prevalence and Antimicrobial Resistance of Salmonella Isolated From Dead-in-Shell Chicken Embryos in Shandong, China. Front. Vet. Sci. 8:581946. doi: 10.3389/fvets.2021.581946

14.Yakun Wang†, Xue Zhou†,  Hanzhu Wang, Lingyu Sun, Bingxiang Wang, Yingying Jiang, Huihui Li, Xiao Zhang, Hongmei Li, ⁎, Xiaomin Zhao , ⁎, The role of Eimeria tenella EtCab protein in the attachment and invasion of host cells, Veterinary Parasitology, 292 (2021) 109415, https://doi.org/10.1016/j.vetpar.2021.109415.  

15.Ningning Zhao, Ming Shuzhen, Sun Lingyu, Wang Bingxiang, Li Hongmei, Zhang Xiao*, Xiaomin Zhao*. Identification and characterization of Eimeria tenella microneme protein EtMIC8, Microbiolgy Spectrum,  2021 Sep 3; 9(1):e0022821. doi: 10.1128/Spectrum.00228-21. Epub 2021 Aug 25.

16.Jinwen Wang, Qianqian Tan, Junpeng Chen, Xiaomei Liu,1 Zeyan Di, Qianqian Xiao, Jinxuan Li, Xiaomin Zhao* , and Xiao Zhang* , Alkyl Hydroperoxide Reductase as a Determinant of Parasite Antiperoxide Response in Toxoplasma gondii, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 1675652, 11 pages,  https://doi.org/10.1155/2021/1675652

17.Qianqian Tan , Jinwen Wang , Junpeng Chen , Xiaomei Liu , Xiao Chen ,  Qianqian Xiao , Jinxuan Li , Hongmei Li , Xiaomin Zhao*, Xiao Zhang* , Involvement of Urm1, a Ubiquitin-Like Protein, in the Regulation of Oxidative Stress Response of Toxoplasma gondii,  Microbiolgy Spectrum,  2022 Apr 27;10(2):e0239421. doi: 10.1128/spectrum.02394-21.